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New cyclic compound having pyrimidinylalkylthio group
专利权人:
SANTEN PHARMACEUTICAL CO.; LTD.
发明人:
TAJIMA, HISASHI,HONDA, TAKAHIRO,KAWASHIMA, KENJI,OKAMOTO, KAZUYOSHI,YAMAMOTO, MINORU
申请号:
ES06730773
公开号:
ES2548729T3
申请日:
2006.03.31
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the following general formula (1) or a salt thereof: ** Formula ** in which in the general formula (1), the ring X represents: ** Formula ** R1 represents a phenyl group, a 3-chlorophenyl group, a 4-chlorophenyl group, a 4-methoxyphenyl group, a 4- trifluoromethoxyphenyl group, a 4-n-propylphenyl group, a 3-isopropylphenyl group, a 4-tert-butylphenyl group, a 3- trifluoromethylphenyl group , a 5-chloro-2,4-dimethoxyphenyl group, a 3,5-dimethylphenyl group, an indan-5-yl group, a 1H-indazol-6-yl group, a quinolin-6-yl group or an isoquinolin group -3-yl; R2 represents a hydrogen atom; R3 represents a hydrogen atom, an amino group, a methylamino group, an n-butylamino group, a dimethylamino group, a 2-hydroxyethylamino group, a 2-ethoxyethylamino group, a 1-phenylethylamino group, a 2- morpholinoethylamino group, a cyclopropylamino group, a cyclobutylamino group, a 4-hydroxycyclohexylamino group, an acetylamino group, a diacetylamino group, a methylthio group, a morpholino group, a piperazinyl group, a 4- methylpiperazinyl group or a 4- (2-hydroxyethyl) piperazinyl group; A1 represents a sulfur atom; and A2 represents a methylene group.Un compuesto representado por la siguiente fórmula general (1) o una sal del mismo:**Fórmula** en la que en la fórmula general (1), el anillo X representa:**Fórmula** R1 representa un grupo fenilo, un grupo 3-clorofenilo, un grupo 4-clorofenilo, un grupo 4-metoxifenilo, un grupo 4- trifluorometoxifenilo, un grupo 4-n-propilfenilo, un grupo 3-isopropilfenilo, un grupo 4-terc-butilfenilo, un grupo 3- trifluorometilfenilo, un grupo 5-cloro-2,4-dimetoxifenilo, un grupo 3,5-dimetilfenilo, un grupo indan-5-ilo, un grupo 1H- indazol-6-ilo, un grupo quinolin-6-ilo o un grupo isoquinolin-3-ilo; R2 representa un átomo de hidrógeno; R3 representa un átomo de hidrógeno, un grupo amino, un grupo metilamino, un grupo n-butilamino, un grupo dimetilamino, un grupo 2-hidroxietilamino, un grupo 2-etoxietilamino, un grupo 1-fenil
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