Aryl metiloxi - benzamide Compounds, Pharmaceutical composition containing same and their use for the manufacture of a Medicament useful for the Treatment or prophylaxis of Parkinson's disease
An aryl-methyloxy-benzamide compound of formula (1) or a salt thereof in which A represents pyridin-2-yl, pyridin-3-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-5 -yl, 1,3-oxazol-2-yl, 1H-pyrazol-4-yl or isoxazol-4-yl or a group of formula (2) in which * represents the point of attachment, where when A represents pyridin-3-yl, the pyridinyl ring may be optionally substituted at the 2-position with fluoro, methoxy or CH2OH, at the 4-position with methyl or CH2OH, or at the 5-position with fluoro； when A represents 1H-pyrazol-4-yl, the pyrazolyl ring may be optionally substituted at the 1-position with methyl, and when A represents isoxazol-4-yl,R1 and R2 represent halogenated, halogenated c1-3, (CH2) N8, (CO) R8, heterocyclic ring containing selective nitrogen, and are replaced by one, two or three groups of selected methyl and trifluoromethane； N stands for 1, 2 or 3； R3, R4, R5, R6 and R7 stand for hydrogen, halogen, CN, c1-3 tar or alcoxi c1-3； R8 stands for hydrogen or - nr9r10； R9 and R10 are independent of hydrogen and c1-3 tar； in c1-3 tar, c1-3 tar can be replaced by one, two or three hydrogen halide groups.Ciano or alcoxi C1-2, or together with the nitrogen atom attached to them, form a single ring containing nitrogen, which can be replaced by one, two or three selected groups of halogen, methyl and trifluoromethane； R11 represents hydrogen, halogen, CN, C1-2 tar, alcoxi C1-2, - ch2co2h or -Conhch3. These compounds inhibit the kunsa activity of LRRK2. Pharmaceutical ingredients, including those used to produce drugs for the treatment or prevention of Parkinson's or Alzheimer's disease.Un compuesto de aril-metiloxi-benzamida de fórmula (1) o una sal del mismo en la que A representa piridin-2-ilo, piridin-3-ilo, piridazin-3-ilo, piridazin-4-ilo, pirimidin-5-ilo, 1,3-oxazol-2-ilo, 1H-pirazol-4-ilo o isoxazol-4-ilo o un grupo de fórmula (2) en la que * representa el punto de unión, en la que cuando A representa piridin-3-ilo, el anillo piridinilo puede estar op
