The present invention relates to a composition for preventing and treating muscle-related diseases, which comprises a compound isolated from garlic extract or a pharmaceutically acceptable salt thereof as an active ingredient. Therefore, the inventors of the present invention intend to improve the activity of a natural product or a health functional food material with enhanced activity that can be utilized for the purpose of prevention and treatment of muscle-related diseases. (1) To evaluate the effect of (1) myocyte differentiation, Western blotting analysis of the degree of MHC expression in the differentiated C2C12 cells revealed that the inventor of the present invention had already applied the patented azoen content enhanced extraction method (Example 2), (2) the EW extract fraction of the present invention increased the expression of MHC and myoD by the extract fraction of EW, In addition, it was confirmed that the differentiation into cylinder-shaped polynucleated myotubes was induced in a concentration-dependent manner (Experimental Example 3). (3) MHC expression and the formation of cylindrical polynuclear canaliculus cells were increased by the azoenes of the present invention (Experimental Example 4), (4) increased myoD and myogenin expression during myogenetic differentiation, p38 MAPK signal transduction system was activated (Experimental Example 5), (5) muscle loss using a culture medium of CT-26 colorectal cancer cell line In an in vitro experimental model, (6) The CT-26 colon cancer cell line was subcutaneously injected into BALB / c mice to induce cancer cachexia. The expression of MHC and myoD was restored to the normal level. In one animal experimental model ( in vivo ), it was confirmed that the EW extract fraction of the present invention inhibited muscle loss by cancer (Experimental Example 7). As a result of the above experiment, it was confirmed that the garlic extract of the present invention and the compound isolated therefrom could be use
