Antigen-binding molecules with controlled association of heavy and light chains

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专利权人:

中外製薬株式会社

发明人:

倉持 太一,川添 明里,廣庭 奈緒香,井川 智之

申请号：

JP2013541800

公开号：

JP6371059B2

申请日:

2012.10.31

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

It was found that association between CH1 and CL can be suppressed by substituting amino acids that exist on the interface between CH1 and CL with electrically-charged amino acids, and that formation of heterogeneous molecules is enabled more efficiently than by introducing knobs into holes mutations into CH3 domain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/