SANOFI;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
申请号：
ARP160103249
公开号：
AR106466A1
申请日:
2016.10.25
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
This report provides three and / or trivalent binding proteins, which are composed of four polypeptide chains, forming three antigen binding sites, specifically connected to one or more HIV targets or one or more T cell receptors. In the first pair of peptides, there are two kinds of peptides with cross direction variable domain, and the second pair of peptides with single variable domain. This report also provides protein processing methods.3. To treat and / or prevent HIV / AIDS, three specific and / or trivalent conjugates and the use of such conjugated proteins. Requirement 1: binding protein, consisting of four polychlorinated diphenyl ether chains, forming three antigen binding sites, binding to one or more specific HIV targetsa. The first polyacrylic acid chain is composed of the structure represented by the formula: vl83222a-l8321a-vl832221-l832222-cl [1]； the second polyacrylic acid chain is composed of the structure represented by the formula: vh8321a-l832323a-vh83224a-ch8321a [2]； a The third polychlorinated two phenyl ether chain is composed of the structure represented by the following formula: VH8323-CH8321[3]； the fourth polychlorinated two phenyl ether chain is composed of the structure represented by the following formula: Vl8323-CL[4]； wherein, VL83221 is the first variable domain of immunoglobulin light chain； VL8322 is the second variable domain of light chain； Vl832323 is the third variable domain of immunoglobulin light chain；Vh83212a is the first variable domain of immunoglobulin heavy chain； vh832222 is the second variable domain of immunoglobulin heavy chain； vhc23 is the third variable domain of immunoglobulin heavy chain； CL is a continuous domain of immunoglobulin light chain； a. Ch832121 is a constant high chain domain ch83217a；L83222,L8323,Dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichlorodibenzo dichloro
