INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIPO I PCT Hu onion °nolo mu olomomilioluo ois (10) International Publication Number WO 2018/191479 Al (51) International Patent Classification: C07K 16/24 (2006.01) A61K 39/00 (2006.01) C07K 14/715 (2006.01) (21) International Application Number: PCT/US2018/027271 (22) International Filing Date: Published: — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) 12 April 2018 (12.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/484,864 12 April 2017 (12.04.2017) US 62/553,477 01 September 2017 (01.09.2017) US 62/553,575 01 September 2017 (01.09.2017) US (71) Applicants: AMGEN INC. [US/US]； One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). MEDIM- MUNE LLC [US/US]； One Medlmmune Way, Gaithers- burg, MD 20878 (US). (72) Inventors: PARNES, Jane, R.； 5832 Midddle Crest Dri- ve, Agoura Hills, CA 91301 (US). GRIFFITHS, Janet； C/ o Medlmmune LLc, One Medlmmune Way, Gaithersburg, MD 20878 (US). (74) Agent: NEVILLE, Katherine, L. et al.； Marshall, Ger- stein & Borun Llp, 233s. Wacker Drive, 6300 Willis Tower, Chicago, IL 60606-6357 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK,
