The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a Fe compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I) Cs () Title: THERAPEUTIC COMPOUNDS AND METHODS 00 N 1-1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT ill 1111u°11111VIIIVIIII o mu oloitionoiflo oimIE (10) International Publication Number WO 2018/191789 Al (51) International Patent Classification: CO7C 50/12 (2006.01) A61K 31/401 (2006.01) C07C 233/48 (2006.01) A61K 31/4015 (2006.01) C07C 233/19 (2006.01) A61K 31/198 (2006.01) C07C 233/10 (2006.01) A61K 31/223 (2006.01) C07C 53/136 (2006.01) A61K 31/192 (2006.01) C07C 323/61 (2006.01) A61K 31/122 (2006.01) C07D 207/16 (2006.01) A61P 39/06 (2006.01) (21) International Application Number: PCT/AU2018/050360 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2017901457 21 April 2017 (21.04.2017) AU (71) Applicant: UNIVERSITY OF TASMANIA [AU/AU]； Churchill Avenue, Sandy Bay, Tasmania 7001 (AU). (72) Inventors: GUVEN, Nuri； 7 Lapoinya Rd, Fern Tree, Tasmania 7054 (AU). SMITH, Jason； 11A Willowbend Road, Kingston, Tasmania 7050 (AU). WOOLLEY, Krys- tel Lee； 4/175 Main Road, Huonville, Tasmania 7109 (AU). NADIKUDI, Monila； 13 Eldonhurst Drive, Newstead, Tas- mania 7250 (AU). (74) Agent: DAVIES COLLISON CAVE PTY LTD； Level 15, 1 Nicholson Street, Melbourne, Victoria 3000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD
