TREATMENT OF HER2 POSITIVE CANCERS

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专利权人:

INC.;SEATTLE GENETICS

发明人:

PETERSON, Scott,WALKER, Luke

申请号：

SG11201909676W

公开号：

SG11201909676WA

申请日:

2018.04.27

申请国别(地区):

SG

年份:

2019

代理人:

摘要：

IS- Vehicle Control Tucatinib: nv/kg/close, PO, BID x26 -a- Trastuzumab: 20 mg/kg/dose, P. Q3D x9 Tucatinib + Trastuzumab FIG. 5C Anti-Tumor Effect of Tucatinib and Trastuzumab in Gastric Cancer PDX GXA 3054 Group Mean (n=10) Tumor Volume ± SD 500 'E 400 E 300 200 8 100 14 21 28 Study Day 1-1 1-1 1-1 00 1-1 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT omit VIII °nolo Holollm olollm mom° oimIE (10) International Publication Number WO 2018/201016 Al (51) International Patent Classification: A61K 39/395 (2006.01) A61K 31/7068 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/029899 (22) International Filing Date: 27 April 2018 (27.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/491,872 28 April 2017 (28.04.2017) US (71) Applicant: CASCADIAN THERAPEUTICS, INC. [US/US]； 2601 4th Ave., Suite 500, Seattle, Washington 98121 (US). (72) Inventor: PETERSON, Scott； c/o Cascadian Therapeu- tics, Inc., 2601 4th Ave., Suite 500, Seattle, Washington 98121 (US). (74) Agent: ZYLSTRA, Eric J. et al.； Kilpatrick Townsend & Stockton LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.

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