A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1) a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuumplugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23). The dissolving solution can be easily filled in a bubble-free state in the two-chamber type combined container-syringe.【課題】溶解液を容易にバブルフリー充填することが可能な二室式容器兼用注射器の製造方法を提供する。【解決手段】溶解液充填工程S1の後に、溶解液充填カートリッジの溶解液から気泡を除去して該溶解液をミドルストッパーで封止する真空打栓工程S2を備え、該真空打栓工程S2は、溶解液充填カートリッジが配置される真空打栓装置内を溶解液が凍結しない冷却温度まで冷却する第一冷却処理S21と、該第一冷却処理S21の後に、真空打栓装置を冷却温度に維持したまま真空打栓装置内を減圧する第一減圧処理S23と、該第一減圧処理S23の後に、ミドルストッパーを下方に押し込んで溶解液に接触させるミドルストッパー押し込み処理S24とを有する。【選択図】図1
