Disclosed is a method for producing exosomes having effects of skin regeneration and wound healing, comprising the steps of: providing ultrasonic stimulation directly or indirectly to cells； culturing a mixture of the cells and a medium for a predetermined amount of time； and separating exosomes from the mixture, wherein direct provision of stimulation is the application of ultrasonic stimulation to a medium comprising cells, and indirect provision of stimulation is the application of ultrasonic stimulation to a medium that does not comprise cells and then mixing the medium with the cells. The exosome production method enables exosomes, having effects of skin regeneration and wound healing, to be obtained in a high yield and short amount of time by means of a simple process called sonication from stem cells, which are difficult to be handled, and also from somatic cells, which can be easily obtained and maintained. The exosomes obtained thereby also have a high amount and number of various included factors, the exosomes and compositions comprising same have increased various factors, which can induce skin regeneration and wound healing, and the exosomes have a phospholipid-based membrane structure so as to facilitate skin penetration and allow high efficiency of substance delivery, thereby enabling skin regeneration and wound healing to be effectively induced, and are safe and have no side effects caused by the use of synthetic drugs.L'invention concerne un procédé de fabrication d'exosomes ayant des effets de régénération de la peau et de cicatrisation des plaies, comprenant les étapes suivantes : stimulation ultrasonore directe ou indirecte de cellules ； culture d'un mélange cellulaire et d'un milieu pendant une durée prédéterminée ； et séparation des exosomes et du mélange, la stimulation directe étant l'application d'une stimulation ultrasonore à un milieu qui comprend des cellules, et la stimulation indirecte étant l'application d'une stimulation ultrasonore à
