GEORGIA TECH RESEARCH CORPORATION;EMORY UNIVERSITY
发明人:
NEISH, ANDREW, S.,CHAMPION, JULIE, A.
申请号：
EP14778712
公开号：
EP2970399A4
申请日:
2014.03.11
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the particles are made by the process of producing recombinant proteins and conjugating the recombinant proteins to form nanoparticles with a linking reagent comprising disulfide bonds. Typically the recombinant protein has a polypeptide of viral, fungal, or bacterial origin such as secreted effector proteins AvrA and YopJ. In certain embodiments, the disclosure relates to treating or preventing autoimmune diseases, cancer, or inflammatory diseases, or conditions such as inflammatory bowel disease (IBD).
