ДИСЭЙ Нейл П. (US),ПЕЙКОВ Виктор (US),СООН-ШИОНГ Патрик (US)
申请号：
RU2011146132/15
公开号：
RU2011146132A
申请日:
2010.04.15
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition containing nanoparticles comprising albumin and a substantially water insoluble pharmacologically active agent in which prion protein is substantially absent. The composition according to claim 1, which is characterized by prion infectivity of less than about 100 fg / ml or less than about 10 units / ml or both. The composition according to claim 1, in which there is no prion protein according to the results of the analysis by the method of cyclic amplification with an incorrect folding of the protein chain (RMSA) or analysis by the method of PCR. 4. The composition according to claim 2, in which there is no prion protein according to the results of the analysis by cyclic amplification method with incorrect folding of the protein chain (RMSA) or analysis by IPCR. A composition according to any one of claims 1 to 4, which further comprises a trace amount of a ligand capable of binding to a prion protein, or a trace amount of a carrier, or both. A composition comprising nanoparticles comprising albumin and a substantially water-insoluble pharmacologically active agent, wherein albumin was prepared by a process including a prion removal process, said removal process comprising contacting an initial albumin composition with a ligand capable of binding to a prion protein .7. The composition of claim 6, wherein the prion removal process further comprises removing said ligand and its associated proteins from said albumin and composition. The composition of claim 7, wherein the ligand is a peptide. The composition of claim 7, wherein the ligand is a triazine-based compound. A method of obtaining a composition containing nanoparticles comprising albumin and a substantially water-insoluble pharmacological1. Композиция, содержащая наночастицы, включающие альбумин и, по существу, не растворимый в воде фармакологически активный агент, в которой, по существу, отсутствует прионный белок.2. Композиция по п.1, которая характеризуется инфективностью приона менее прим
