UNIVERSIDADE DE SÃO PAULO-USP;UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL
发明人:
ADRIANA RAFFIN POHLMANN,DULCINÉIA SAES PARRA ABDALLA,EDUARDO ANDRÉ BENDER,MARCELA FROTA CAVALCANTE,SÍLVIA STANISÇUASKI GUTERRES
申请号：
BRPI1106193
公开号：
BRPI1106193A2
申请日:
2011.10.11
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
synthetic process for the production and use of multi-wall nanocapsules complexed with metal ions. The present invention is directed to the synthetic process for producing multiparule nanoparticles complexed with metals or metal ions, such as alkaline or alkaline earth metals, transition or rare earth metals, including silver, gold, platinum, copper, cadmium, cobalt, palladium. , more especially iron or zinc, which allows the attachment of small molecules, macromolecules or biomolecules of synthetic, biosynthetic or natural origin, such as proteins, peptides, phenols, amines, carboxylic acids, saccharides, alkaloids, ribonucleic or deoxyribonucleic acids , aptamers, antibodies, monoclonal antibodies and especially amino acids, proteins, enzymes and antibody fragments, constituting an innovation for the development of functionalized or multifunctional surface nanoparticulate systems. The invention provides for the use of the synthetic process for the functionalization of the colloidal surface to produce decorated multiparous nanoparticles, and decorated multiparous nanocapsules can be used for the diagnosis of health diseases such as gene therapy, cancer, inflammation, degenerative diseases. .processo sintético para a produção e uso de nanocápsulas multiparedes complexadas com íons metálicos. a presente invenção trata do processo sintético para a produção de nanopartículas multiparedes complexadas com metais ou íons metálicos, como por exemplo metais alcalinos ou alcalino terrosos, metais de transição ou terras raras, incluindo prata, ouro, platina, cobre, cádmio, cobalto, paládio, mais especialmente ferro ou zinco, que permite a ligação de pequenas moléculas, macromoléculas ou biomoléculas de origem sintética, biossintética ou natural, como, por exemplo, proteínas, peptideos, fenóis, aminas, ácidos carboxilicos, sacarideos, alcalóides, ácidos ribonucíéicos ou desoxirribonucléicos, aptameros, anticorpos, anticorpos monoclonais e especialmente aminoácidos, proteínas,
