(57)< Abstract > This invention, (a) was padded in the non bloating tendency non erosion Characteristic hydrophobic matrix consists of the active medicine which the core formation which, (b) to be applied by 1 surfaces of core formation, canning that by the surface of opposite side (of c) core formation and the first barrier formation, and to be applied canning that the optional second barrier formation to consist of, the core, approximately 80 weight % the active medicine below and approximately 5 weight % - approximately 80 weight % to consist of the insoluble polymer material in the non bloating tendency wax or in water media, and first and second barrier formation in independence(1) in water media high-level swelling and the polymer material which shows gelation or (2) the insoluble polymer material is included in the non bloating tendency wax or water media, the tablet for control discharge of active medicine is offered.本発明は、(a)非膨潤性非浸食性疎水性マトリックスの中に埋め込まれた活性薬剤からなるコア層、(b)コア層の1個の面に適用され、それを被覆する第一バリヤー層、及び(c)コア層の反対側の面に適用されそれを被覆する任意の第二バリヤー層からなり、コアが、約80重量%以下の活性薬剤及び約5重量%~約80重量%の非膨潤性ろう又は水性媒体中に不溶性のポリマー材料からなり、そして第一及び第二バリヤー層が独立に、(1)水性媒体中で高度の膨潤及びゲル化を示すポリマー材料又は(2)非膨潤性ろう若しくは水性媒体中で不溶性のポリマー材料を含む、活性薬剤の制御放出用錠剤を提供する。
