The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.本發明提供新穎普拉二烯內酯化合物、含有該等化合物之醫藥組合物及用於使用該等化合物作為治療劑之方法。此等化合物可適用於治療癌症，尤其為已知適用靶向剪接體及其中之突變的藥劑之癌症。本發明亦提供藉由投與至少一種本文所揭示之化合物及至少一種額外療法來治療癌症之方法。
