FRIGOLA-CONSTANSA, JORDI,MERCE-VIDAL, RAMON,HOLENZ, JOERG,ALCALDE PAIS, MARIA DE LAS ERMITAS,MESQUIDA ESTEVEZ, MARIA DE LES NEUS,LOPEZ PEREZ, SARA
申请号：
ES06818389
公开号：
ES2384642T3
申请日:
2006.11.07
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
An indene derivative of general formula I: ** Formula ** in which n is 0, 1, 2, 3 or 4R1 represents a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally with at least one heteroatom selected from N, O and S as a member of the ring that can be condensed with an optionally at least mono-substituted mono or polycyclic ring system； a radical -NR8R9； a radical -CONR8R9； -COOH； or -OH in which R8 and R9 represent, independently of one another, a hydrogen atom； or a linear, saturated or unsaturated C1-5 linear aliphatic radical, which may be substituted with 1, 2, 3 substituents independently selected from F, Cl, Br, -OH, -NH2, -SH, -O-CH3, -O- C2H5, -NO2, -CN, -NH-CH3 and -S-CH3； oR8 and R9 together with nitrogen form a saturated 3- to 9-membered heterocyclic ring, oaromatic unsaturated, which can be substituted with 1, 2 or 3 substituents independently selected from C1-5-alkyl, -O-C1-5-alkyl, -S-C1-5-alkyl, oxo (>； = O), thioxo (>； = S), -C (>； = O) -OH , -C (>； = O) -O-C1-5-alkyl, -OC (>； = O) -C1-5-alkyl, F, Cl, Br, I, -CN, -CF3, -OCF3, -SCF3 , -OH, -SH, -NH2, -NH (C1-5-alkyl), -N (C1-5-alkyl) 2, -NO2, -CHO, -CF2H, -CFH2, -C (>； = O) -NH2, -C (>； = O) -NH (C1-5-alkyl), -C (>； = O) -N (C1-5-alkyl) 2, -S (>； = O) 2-C1-5 -alkyl, -S (>； = O) 2-phenyl and which may contain 1, 2 or 3 additional heteroatoms independently selected from N, O and S as ring members R2, R3, R4 and R5 represent, a hydrogen atom, - F, Cl, Br or I； with the proviso that at least one of the substituents R2, R3, R4 and R5 represents a radical -S (>； = O) 2-N (R14) R15； A represents: what it means, compounds type (Iy):Un derivado de indeno de formula general I: **Fórmula**en la quen es 0, 1, 2, 3 o 4R1 representa un radical cicloalifático saturado o insaturado, opcionalmente al menos monosustituido,opcionalmente al menos con un heteroatomo seleccionado entre N, O y S como miembro del anillo que puedeestar condensado con un sistema anula
