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Pharmaceutical compositions of pyridinium and quinolinium derivatives
专利权人:
TRASLATIONAL CANCER DRUGS PHARMA; S.L.
发明人:
PALACIOS IZQUIERDO, BEATRIZ,VAN HOOGEVEST, PETER,L.S. LEIGH, MATHEW
申请号:
ES11805029
公开号:
ES2529673T3
申请日:
2011.12.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A composition comprising: (a) at least one compound of formula (I): ** formula ** in which Q- represents the conjugate base of a pharmaceutically suitable organic or inorganic acid; R1 and R'1 are independently selected from hydrogen and substituted or unsubstituted C1-6 alkyl; R2 and R2 are independently selected from a substituted or unsubstituted aryl radical; R3 and R'3 are independently selected from hydrogen, halogen, -CF3, -OH, -NH2, -O-C1-6 alkyl and substituted or unsubstituted C1-6 alkyl; or R3 and R'3 together with R4 and R'4 respectively, and independently of each other, form a radical -CH>; = CH-CH>; = CH- substituted or unsubstituted; R4 and R'4 are independently selected from hydrogen, halogen, -CF3, -OH, -NH2, -O-C1-6 alkyl and substituted or unsubstituted C1-6 alkyl; or R4 and R'4 together with R3 and R'3 respectively, and independently of each other, form a radical -CH>; = CH-CH>; = CH- substituted or unsubstituted; m is 0 or 1; n is an integer selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10; p is 0 or 1; with the proviso that m, n and p are not zero at the same time; or a solvate thereof, and (b) at least one cyclodextrin or a liposome.Una composición que comprende: (a) al menos un compuesto de fórmula (I):**fórmula** en la que Q- representa la base conjugada de un ácido orgánico o inorgánico farmacéuticamente adecuado; R1 y R'1 se seleccionan independientemente de hidrógeno y alquilo C1-6 sustituido o no sustituido; R2 y R'2 se seleccionan independientemente de un radical arilo sustituido o no sustituido; R3 y R'3 se seleccionan independientemente de hidrógeno, halógeno, -CF3, -OH, -NH2, -O-alquilo C1-6 y alquilo C1-6 sustituido o no sustituido; o R3 y R'3 junto con R4 y R'4 respectivamente, e independientemente uno de otro, forman un radical -CH>;=CH-CH>;=CH- sustituido o no sustituido; R4 y R'4 se seleccionan independientemente de hidrógeno, halógeno, -CF3, -OH, -NH2, -O-alquilo C1-6 y alquilo C1-6 sustituido o no sustituido; o R4
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