Gang Chen,Umesh B. Gangadharmath,Dhanalakshmi Kasi,Harmuth C. Kolb,Changhui Liu,Anjana Sinha,Anna Katrin Szardenings,Joseph C. Walsh,Eric Wang,Chul Yu,Wei Zhang,Klaus Kopka,Guenter Haufe,Michael Schae
申请号：
US13849646
公开号：
US09023318B2
申请日:
2013.03.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.
