Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof 0.005 wt.% to 0.15 wt.% of hyaluronic acid and 0.01 wt.% to 1.0 wt.% of an amphoteric surfactant of general formula Iwherein R1 is R or -(CH2)n-NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4 R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
