BLINN, James Robert,FLICK, Andrew Christopher,WENNERSTÅL, Göran Mattias,JONES, Peter,KAILA, Neelu,KIEFER, James Richard Jr.,KURUMBAIL, Ravi G.,MENTE, Scot Richard,MEYERS, Marvin Jay,SCHNUTE, Mark Edwa
申请号：
ES14767126
公开号：
ES2685839T3
申请日:
2014.07.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula II: ** Formula ** or a pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof, wherein, Y is hydrogen, halo, cyano, (C1-C3) alkyl, hydroxyalkyl (C1-5 C3), (C1-C5) alkenyl, halo (C1-C3) alkyl, hydroxy (C1-C3) -haloalkyl, cycloalkyl (C3-C6), alkoxy (C1-C3) or haloalkoxy (C1-C3)； R1 is hydrogen, (C1-C6) alkyl, hydroxyalkyl (C1-C6) or haloalkyl (C1-C6)； X is ** Formula ** W is ** Formula ** optionally substituted with one, two, three, four or five independently selected substituents each time they are present from the group consisting of halo, (C1-C6) alkyl, hydroxyalkyl (C1-C6) and haloalkyl (C1-C6)； R3 is (C1-C6) alkyl, (C3-C8) cycloalkyl, (C3-C8) heterocycloalkyl, aryl, heteroaryl, -C (>； = O) R4, -C (>； = O) OR4, - C (>； = O) N (R5) 2 or -S (>； = O) 2R4, optionally substituted with one, two, three, four or five independently selected substituents each time they are present among the group consisting of halo, cyano, (C1) alkyl -C4), halo (C1-C4) alkyl, cyanoalkyl (C1-C4), hydroxyl, hydroxyalkyl (C1-C4), alkoxy (C1-C4), alkoxy (C1-C4) alkyl (C1-C4), haloalkoxy (C1 -C4), -NR2, (R2N) alkyl (C1-C4) -, alkylthio (C1-C4), haloalkylthio (C1-C4), -C (>； = O) R, -C (>； = O) OR, -OC (>； = O) R, -C (>； = O) NR2, -N (R) C (>； = O) R, -CH2C (>； = O) R, -CH2C (>； = O) OR, - CH2OC (>； = O) R, -CH2C (>； = O) NR2, -CH2N (R) C (>； = O) R, -S (>； = O) 2R, -S (>； = O) 2NR2, -N (R) S (>； = O) 2R, -A and -CH2A； R4 is hydrogen, (C1-C6) alkyl, (C3-C8) cycloalkyl, (C3-C8) heterocycloalkyl, (C3-C8) cycloalkyl (C1-C6) alkyl, hetero (C3-C8) alkyl (C1-C6) alkyl , aryl or heteroaryl, optionally substituted with one, two, three, four or five independently selected substituents each time they are present from the group consisting of halo, cyano, (C1-C4) alkyl, haloalkyl (C1-C4), cyanoalkyl (C1-C4), hydroxyl, hydroxyalkyl (C1-C4), alkoxy (C1-C4), alkoxy (C1-C6) alkyl (C1-C6), haloalkoxy (C1-C6), -NR2, (R2N) alkyl ( C1-C
