Thomas Schrader;Julia März-Berberich;Gal Bitan;Luitgard Nagel-Steger;Sharmistha Sinha;Katrin Hochdörffer
发明人:
Thomas Schrader,Katrin Hochdörffer,Julia März-Berberich,Luitgard Nagel-Steger,Gal Bitan,Sharmistha Sinha
申请号：
US13504325
公开号：
US20120270795A1
申请日:
2010.01.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.
