The present invention relates to a method and device for treating patients with a Protein Misfolding Disease by chronically administering an effective dose of a thormbolytic reagent over an intermittent period of time. The thrombolytic reagents degrade the misfolded proteins that accumulate and that can become toxic in such patients. The administration is administered transdermally via a transdermal patch that is equipped with an ultrasound transducer for enhancing the penetration of the thrombolytic reagent into the bloodstream of a patient by increasing the permeability of the patient's skin.
