The present disclosure provides hNGAL muteins that bind CGRP and can be used in various application including pharmaceutical applications, for example, migraine. The present disclosure also concerns methods of making one or more muteins described herein as well as compositions and combinations comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions and combinations comprising one or more of such muteins.本發明提供結合CGRP的hNGAL突變蛋白，且該突變蛋白可以用於各種應用，包括醫藥應用，例如偏頭痛。本發明還涉及製備本文所述之一或多種突變蛋白的方法以及包含一或多種該等突變蛋白之組合物及組合。本發明進一步涉及編碼這種突變蛋白的核酸分子以及產生這種突變蛋白及核酸分子的方法。此外，本申請公開了這些突變蛋白的治療及/或診斷的用途以及包含一或多種這種突變蛋白的組合物及組合。
