The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.本發明概括性地提供結合兩個表位(例如，第一及第二表位)且呈二價用以結合至該等第一及第二表位中之每一者的蛋白。本發明亦提供結合至靶蛋白之特異性結合蛋白，包括抗體。本發明亦提供包含該等蛋白之組合物、編碼該等蛋白之核酸分子及製備該等蛋白之方法。本發明提供誘導個體免疫反應之方法以及治療或預防個體癌症之方法，其係藉由向該個體投與該等蛋白、核酸分子及/或組合物來實施。
