Modified antibody with improved half-life

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专利权人:

Teva Pharmaceuticals Australia Pty Ltd

发明人:

WILSON, David,TAURA, Tetsuya

申请号：

ES11850362

公开号：

ES2720136T3

申请日:

2011.12.22

申请国别(地区):

ES

年份:

2019

代理人:

摘要：

The present invention relates to antibodies, immunoglobulin constructs or immunoglobulin IgG4 fusion proteins whose in vivo half-lives are increased by the combination of (i) a modified IgG4 Fc region or FcRn binding domain thereof and (ii) a modified IgG4 hinge region sequence.

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