Pierre Van Antwerpen;Jalal Soubhye;François Dufrasne
发明人:
Jalal Soubhye,François Dufrasne,Pierre Van Antwerpen
申请号：
US13322617
公开号：
US20120122948A1
申请日:
2010.05.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a compound of formula (Ia)whereinn is an integer between 2 and 10,R1 and R2 independently represent a substituent selected from the group consisting of hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl and aminoalkyl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to form a four to ten-membered heterocycle,R5 represents independently in each of the n units a substituent selected from the group consisting of hydrogen, C1-C10 alkyl, halogen, alkoxy, aminoalkyl and alkylamino；or a pharmaceutically acceptable salt thereof, with the proviso that the 5-fluorotryptamine is excluded, for the treatment or the prophylaxis of neuroinflammatory diseases or disorders. The invention also relates to a pharmaceutical composition, a method for inhibiting myeloperoxidase enzyme activity, to a method for inhibiting Low density lipoproteins oxidation.
