COMPOSITIONS DESTINEES A ETRE UTILISEES EN TANT QU'AGENT PROPHYLACTIQUE POUR DES PERSONNES PRESENTANT UN RISQUE D'INFECTION DE LA TUBERCULOSE, OU EN TANT QU'AGENTS SECONDAIRES POUR TRAITER DES PATIENTS INFECTES PAR LA TUBERCULOSE
MARTIN MONTANES, CARLOS,AGUILO ANENTO, JUAN IGNACIO,GONZALO ASENSIO, JESUS ANGEL,MARINOVA, DESSISLAVA VANEVA,UGANDA MAIZ, SANTIAGO,RODRIGUEZ SANCHEZ, ESTEBAN,PUENTES COLORADO, EUGENIA,FERNANDEZ ALVARE
申请号：
CA3091304
公开号：
CA3091304A1
申请日:
2019.02.19
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberculosis complex, preferably a M. tuberculosis clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM- phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberculosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.
