F. HOFFMANN-LA ROCHE AG;GALLEY, Guido;NORCROSS, Roger;PFLIEGER, Philippe
发明人:
GALLEY, Guido,NORCROSS, Roger,PFLIEGER, Philippe
申请号：
EPEP2012/060637
公开号：
WO2012/168265A1
申请日:
2012.06.06
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula (I) wherein R1 is hydrogen, halogen, cyano, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or C(O)NH2, or is phenyl optionally substituted by halogen, cyano or lower alkoxy substituted by halogen, or is 2,2-difluorobenzo[d][1,3]dioxol-5-yl, or is 6-(trifluoromethyl)pyrazin-2-yl or 5-(trifluoromethyl)pyrazin-2-yl or is 6-(trifluoromethyl)pyrimidin-4-yl, or is 6- (trifluoromethyl)pyridin-3-yl, or is 5-cyanopyrazin-2-yl or is 2- (trifluoromethyl)pyrimidin-4-yl； n is 1 or 2 R2 is halogen, lower alkyl or cyano and R3 is hydrogen, or R2 is hydrogen and R3 is halogen, lower alkyl or cyano； X is a bond, -NR'-, -CH2NH- or -CHR'-； R' is hydrogen or lower alkyl； Z is a bond, -CH2- or -O-； Ar is phenyl or is heteroaryl, selected from the group consisting of 1H-indazole-3yl, pyridine-2-yl, pyridine-3-yl, pyridine-4-yl, pyrimidine-5-yl, lH-pyrazole-3-yl, 1H- pyrazole-4-yl or lH-pyrazole-5-yl； or to a pharmaceutically suitable acid addition salt thereof, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.Cette invention concerne des composés de formule (I), ou un sel d'addition d'acide pharmaceutiquement acceptable de ceux-ci, qui peuvent être utilisés pour traiter la dépression, les troubles de l'anxiété, le trouble bipolaire, les troubles déficitaires de l'attention avec hyperactivité (TDAH), les troubles liés au stre
