A use of Streptococcus thermophilus TCI633 strain and/or its metabolites in the manufacture of a medicament and/or a food product is provided, wherein the Streptococcus thermophilus TCI633 strain was deposited at Food Industry Research and Development Institute under the accession number BCRC 910636 and at German Collection of Microorganisms and Cell Cultures (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, DSMZ) under the accession number DSM 28121, the medicament is used for preventing and/or treating osteoporosis, and the food is used for at least one of delaying bone loss, increasing bone density, and strengthening bones.一種使用嗜熱鏈球菌TCI633菌株及/或其代謝產物於製造一藥劑及/或食品之用途，其中該嗜熱鏈球菌TCI633菌株係寄存於財團法人食品工業發展研究所(寄存編號為BCRC 910636)及德國國家菌種保藏中心(DSMZ)(寄存編號為DSM 28121)，該藥劑係用於預防及/或治療骨質疏鬆症，該食品係用於以下之至少一者：減緩骨質流失、加強骨密度、及強化骨骼。
