A skin care combination and manufacturing method thereof are provided. The skin care combination includes micro cluster water, ion compounds, vitamin, amino acid, carbon source and Ectoin. the micro cluster water is the water with 17 O-NMR half peak width smaller than 80 HZ. The ion compounds include one of or any combination of calcium ion, magnesium ion, potassium ion, ferrous ion, zinc ion and copper ion. The vitamin includes one of or any combination of biotin, choline chloride, vitamin B12, folic acid and the derivant thereof, inositol and the derivant thereof, D-Panthenol and the derivant thereof, vitamin B3 and the derivant thereof, vitamin B6 and the derivant thereof. The amino acid includes one of or any combination of human essential amino acid and the derivant thereof, ornithine and the derivant thereof, glutathione and the derivant thereof. The carbon source includes one of or any combination of carbohydrates and sodium pyruvate.
