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PHARMACEUTICAL COMPOSITION
专利权人:
ПЕП-ТОНИК МЕДИКАЛ АБ (SE)
发明人:
УНВЯС-МОБЕРГ Керстин (SE),КАРЛССОН Андерс (SE)
申请号:
RU2013147739/15
公开号:
RU2013147739A
申请日:
2012.04.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A pharmaceutical composition comprising a. oxytocin (SEQ ID NO: 1) and / or one or more of its fragments and / or its variants in accordance with SEQ ID NO: 2, as well as its pharmaceutically acceptable salts and b. at least one non-ionic cellulose ether, where SEQ ID NO: 2 is X-XXX-Asn-Cys-XXXX-NH, in which X is selected from the group consisting of Cys and absence; X is selected from the group consisting of Tyr, Phe and absence; X is selected from the group consisting of Ile, Val, Hoph, Phe, Cha and absence; X is selected from the group consisting of Gln, Ser, Thr, Cit, Arg and Daba; X is selected from the group consisting of Pro and absence; X is selected from the group, consisting of Ile, Leu, absence, Val, Hos, Daba, Thr, Arg and Cit; X is selected from the group consisting of Gly, absence and Ala; X is selected from the group consisting of Gly and absence; where the specified pharmaceutical comp zitsiya has a pH ranging from 3 to 4, with the proviso that the variant is not oxytocin, vasopressin (SEQ ID NO: 7) .2. The pharmaceutical composition of claim 1, wherein said one or more oxytocin fragments and / or variants are selected / selected from the group consisting of peptides in accordance with SEQ ID NOs: 3-6 and 8-24.3. The pharmaceutical composition according to claim 1 or 2, wherein said pH is in the range from 3 to 3.8.4. The pharmaceutical composition of claim 1, wherein said pH is in the range of 3 to 3.5.5. The pharmaceutical composition of claim 1, wherein said pH is in the range of 3 to 3.3.6. The pharmaceutical composition of claim 1, wherein the pH of said composition is adjusted by adding a pH-adjusting agent to said composition. The pharmaceutical composition of claim 6, wherein said pH-adjusting agent is a buffer. The pharmaceutical composition of claim 7, wherein said buffer is a lactate buffer or cit1. Фармацевтическая композиция, содержащаяa. окситоцин (SEQ ID NO:1) и/или один или несколько его фрагментов и/или его вариантов в соответстви
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