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ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ И/ИЛИ ПРОФИЛАКТИКИ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ
专利权人:
ТОРЭЙ ИНДАСТРИЗ; ИНК. (JP)
发明人:
ОКАНО Фумиеси (JP),КОБАЯСИ Синити (JP),МИНАМИДА Еситака (JP),САИТО Таканори (JP)
申请号:
RU2014108043/15
公开号:
RU2014108043A
申请日:
2012.08.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An antibody or fragment thereof which possesses immunological reactivity with CAPRIN-1 protein, wherein the antibody or fragment thereof comprises a heavy chain variable region comprising complementarity determining regions SEQ ID NO: 5, 6 and 7 and the light chain variable region comprising complementarity determining regions SEQ ID NOs: 9, 10 and 11.2. The antibody or fragment thereof according to claim 1, wherein the antibody is a human antibody, humanized antibody, chimeric antibody, single chain antibody or polyspecific antitelo.3. The antibody or fragment thereof according to claim 1 or 2, wherein the antibody or fragment thereof conjugated with anticancer sredstvom.4. A pharmaceutical composition for the treatment and / or prevention of cancer, comprising an antibody or fragment thereof according to any one of claims 1-3 as an active ingredienta.5. A pharmaceutical composition according to claim 4, wherein the malignant tumor is breast cancer, renal cancer, pancreatic cancer, colon cancer, lung cancer, brain tumors, stomach cancer, cervical cancer, ovarian cancer, prostate cancer, bladder cancer bladder, esophagus cancer, leukemia, lymphoma, fibrosarcoma, mastocytoma or melanomu.6. Pharmaceutical combination for the treatment and / or prophylaxis of cancer comprising the pharmaceutical composition according to claim 4 or 5, and a pharmaceutical composition comprising an antitumor sredstvo.7. DNA encoding the antibody or fragment thereof according to claim 1 or 2.8. The method of treatment and / or prophylaxis of cancer comprising administering the antibody or fragment thereof according to any one of claims 1-3, the pharmaceutical composition according to claim 4 or 5 or pharmacist1. Антитело или его фрагмент, который обладает иммунологической реактивностью в отношении белка CAPRIN-1, причем антитело или его фрагмент содержат вариабельную область тяжелой цепи, содержащую определяющие комплементарность области SEQ ID NO: 5, 6 и 7, и вариабельную область легк
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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