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孟魯司特與肽的新共軛物
专利权人:
发明人:
SAMUELSSON, BENGT INGEMAR,山谬森 班杰特 英格玛,山謬森 班傑特 英格瑪,GU, MING,顾铭,顧銘
申请号:
TW108133243
公开号:
TW202023623A
申请日:
2019.09.16
申请国别(地区):
TW
年份:
2020
代理人:
摘要:
There is provided a peptide-containing compound that comprises a peptide component which is an amino acid sequence of from 2 to 45 (e.g. from 6 to 15) amino acids, which peptide component is covalently bonded to one or more compounds of the formula I:wherein:R1is selected from the group consisting of -C(CH3)2OH, -COCH3, -C(CH3)=CH2and -C(CH3)2H; andn is 0, 1 or 2,as well as regioisomers, stereoisomers, and pharmaceutically- or cosmetically-acceptable salts of said peptide-containing compound. The compound of formula I is preferably montelukast, montelukast styrene or hydrogenated montelukast styrene. The peptide-containing compound is particularly useful in the treatment of conditions characterised by inflammation, including wounds, hemorrhoids, burns, psoriasis, acne, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, chronic obstructive pulmonary disease, inflammatory bowel disease (such as. ulcerative colitis). Compounds of the invention are also useful in the treatment of idiopathic pulmonary fibrosis..提供了一種含肽化合物,其包含肽組分,所述肽組分是從2至45個(例如,從6至15個)胺基酸的胺基酸序列,所述肽組分與一個或多個式I的化合物共價鍵合:其中:R1選自由-C(CH3)2OH、-COCH3、-C(CH3)=CH2和-C(CH3)2H所組成的群組;並且n是0、1或2,以及所述含肽化合物的區域異構體、立體異構體、以及藥學上或化妝品可接受的鹽。所述式I的化合物較佳為孟魯司特、孟魯司特苯乙烯或氫化孟魯司特苯乙烯。所述含肽化合物特別可用於治療以炎症為特徵的病症,所述病症包括傷口、痔瘡、燒傷、牛皮癬、痤瘡、異位性皮膚炎、過敏性鼻炎、過敏性結膜炎、慢性阻塞性肺病、炎性腸病(諸如潰瘍性結腸炎)。本發明的化合物還可用於治療特發性肺纖維化。
来源网站:
中国工程科技知识中心
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