AN IMPROVED PROCESS FOR PREPARING MONTELUKAST AND SALTS THEREOF

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专利权人:

发明人:

INDUKURI VENKATA SUNIL KUMAR,MR SIMHADRI SRINIVAS,DR CHAVA SATYANARAYANA

申请号：

IN1284/CHE/2008

公开号：

IN269501B

申请日:

2008.05.26

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

A method for the preparation of montelukast and salts thereof has been described. The method comprises of following steps: (a) (S)-l-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyllpropyl methane sulphonate (styrene mesylate salt) (b) coupling with 1-(mercapto methyl) cyclopropane acetic acid followed by saltification with an amine gives styrene amine salt (c) Converting styrene amine salt to Montelukast amine salt (d) Converting Montelukast amine salt to Montelukast free acid and or its required alkali/alkaline salt

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