Transdermal compositions comprising methylphenidate in a polymer matrix comprising a rubber-based pressure-sensitive adhesive are disclosed, such as a polymer matrix comprising styrene-isoprene-styrene or polyisobutylene polymers. Method of making such compositions, and therapeutic methods using them also are disclosed.本文揭示在包含橡膠基壓敏性黏著劑之聚合物基質(例如包含苯乙烯-異戊二烯-苯乙烯或聚異丁烯聚合物之聚合物基質)中包含哌醋甲酯之經皮組合物。本文亦揭示製備該等組合物之方法及使用該等組合物之治療方法。
