PROCEDE D'INTRODUCTION D'UNE CHAINE LATERALE HYDROXYETHOXY DANS LE BOSENTAN

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专利权人:

GENERICS [UK] LIMITED

发明人:

GAITONDE, ABHAY,MANOJKUMAR, BINDU,SONAWANE, SANDEEP,KOKANE, DATTATREY,MEKDE, SANDEEP,SHINDE, DATTATRAYA,BANSODE, PRAKASH

申请号：

CA2694242

公开号：

CA2694242C

申请日:

2008.06.27

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dirner impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/