Disclosed are various embodiments for devices configured to secure medical lines. A securing frame is configured to receive and secure at least one line couplings. The at least one line coupling is be configured to at least partially surround an intravenous such that the intravenous line is secured in an aperture of the line coupling. The line couplings can be detachably attached to a portion of the securing frame, for example, between concave portions of an upper arm and a lower arm, wherein the upper arm and the lower arm together comprise a latching mechanism. As a result, the securing frame can be latched to further secure the at least one intravenous line. The stability and control provided by the line securing device prevents movement of the intravenous line and/or needle relative to an insertion point on a patient, thereby preventing patient injury.