FENG, Danqing,GUIDRY, Erin N.,HUO, Pei,KAARSHOLM, Niels C.,LIN, Songnian,NARGUND, Ravi P.,YAN, Lin
申请号:
EP16777098
公开号:
EP3280450A4
申请日:
2016.04.04
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Insulin conjugates comprising an insulin analog molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.