A device (10) for delivering a liquid into the skin of a patient has a syringe (12) containing a liquid, and a septum (18) attached to the syringe in sealing relation to a fluid flow outlet (16). A microneedle adapter (20), interengaged with the syringe, has one or more hollow microneedles (22) for insertion into the skin of the patient, and a septum-penetrating hollow projection (24) in facing relation to the septum. When the microneedle adapter (20) is in a storage position, the fluid flow outlet (16) is sealed by the septum (18) for storage of the contained liquid. The microneedle adapter (20) is displaceable to an actuated position in which the septum-penetrating hollow projection (24) penetrates the septum (18), thereby opening a continuous fluid flow path for the liquid from the syringe through the microneedle adapter for injection through the hollow microneedles. An alternative device (100) employs a septum-penetrating projection (116) integrated with an injection molded syringe body (12).
