Rajesh R. Shinde,Rossitza G. Alargova,Patrick Lim Soo,Beata Sweryda-Krawiec,Leila Alland,Christopher Sears
申请号：
US16345306
公开号：
US20190262460A1
申请日:
2017.10.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
