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SSTR-TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
专利权人:
发明人:
Richard Wooster,Kerry Whalen,Patrick Rosaire Bazinet,Mark T. Bilodeau,Sudhakar Kadiyala,Samantha Perino,Beata Sweryda-Krawiec,Rajesh R. Shinde
申请号:
US15770513
公开号:
US20180221499A1
申请日:
2016.10.28
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
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