WOOSTER, RICHARD,WHALEN, KERRY,BAZINET, PATRICK ROSAIRE,BILODEAU, MARK T.,KADIYALA, SUDHAKAR,PERINO, SAMANTHA,SWERYDA-KRAWIEC, BEATA,SHINDE, RAJESH R.
申请号：
CA3001712
公开号：
CA3001712A1
申请日:
2016.10.28
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
