The present invention relates to a pharmaceutical composition for the oral administration of a therapeutic compound of formula (I), which comprises granules that comprise at least therapeutic compound of formula (I) (see below), particularly 2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile or 8-(6-methoxy-pyridin-3-yl)-3-methyl-1-(4-piperazin-1-yl-3-trifluoromethyl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one, or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof； at least one non-ionic surfactant that is Vitamin E-TPGS in an amount ranging from about 15 to about 80% by weight of the composition； and at least one a dissolution enhancing agent selected from polyethylene glycol, polyethylene oxide, and any combination of the foregoing. The present invention also relates to processes for making such pharmaceutical compositions； a kit comprising such pharmaceutical composition and the instructions provide that the pharmaceutical composition may be taken immediately to about thirty minutes after the consumption of food； and related uses and methods of treatment.本發明係關於一種用於經口投與如式(I)之治療化合物之醫藥組合物，該組合物包含顆粒，該等顆粒包含至少如式(I)之治療化合物(參見下文)，特定言之2-甲基-2-[4-(3-甲基-2-側氧基-8-喹啉-3-基-2,3-二氫-咪唑并[4,5-c]喹啉-1-基)苯基]-丙腈或8-(6-甲氧基-吡啶-3-基)-3-甲基-1-(4-哌嗪-1-基-3-三氟甲基-苯基)-1,3-二氫-咪唑并[4,5-c]喹啉-2-酮或其等互變異構體，或其等醫藥可接受鹽或水合物或溶劑化物；該組合物之約15至約80重量%之量之至少一非離子性表面活性劑，該表面活性劑係維生素E-TPGS；及選自聚乙二醇、聚環氧乙烷及以上者之任意組合之至少一溶解增強劑。本發明亦係關於製造該等醫藥組合物之方法；一種套組，該套組包含該醫藥組合物及說明書，該說明書指出該醫藥組合物可在進食後約30分鐘時立即服用；及相關用途及治療方法。
