PROCESS FOR THE PREPARATION OF ATROPINE AND ITS CRYSTALLINE QUATERNARY SALTS THERE OF

• 收藏
• 分享

专利权人:

发明人:

PARVEEN GOYAL,BALDEV RAJ BANSAL,Ramkrushna Ashok Salunke

申请号：

IN201611015904

公开号：

IN201611015904A

申请日:

2016.05.06

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention provides a novel process for preparation of crystalline atropine sulphate monohydrate by esterification reaction of tropine hydrochloride with acetyl protected acid chloride of DL- Tropic acid in organic solvent in inert atmosphere. The condensed acetyl atropine hydrochloride is hydrolyzed in dilute hydrochloric acid to get atropine hydrochloride in aq. Medium which is basified by liquor ammonia and extracted in methylene dichloride and purified in acetonitrile to get good yield and quality of pure atropine. Atropine is then subjected to quaternarization to give its quaternary salt like Atropine sulphate.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/