UNIWERSYTET JAGIELLOŃSKI;WARSZAWSKI UNIWERSYTET MEDYCZNY
发明人:
KRZYSZTOF KAMIŃSKI,MICHAŁ ABRAM,ANNA RAPACZ,SZCZEPAN MOGILSKI,GNIEWOMIR LATACZ,BARTŁOMIEJ SZULCZYK
申请号：
PL428485
公开号：
PL428485A1
申请日:
2019.01.07
申请国别(地区):
PL
年份:
2020
代理人:
摘要：
The subject of the report is a compound with a general pattern (I) or its pharmacologically acceptable salts and their use for the treatment of neurological diseases. In the formula of the above-mentioned compound x- means N or C, k- is the number of 0 or 1, A is the parent selected from the group containing: the phenyl parent； the phenyl parent based on one or two or three or four side bases selected from the group containing: fluoride atoms, -SCF3, -CF3, -CHF2, -CN, -OCF3, -NO2, -OCH3, -OC2H5, an alkyl group having carbon numbers in carbon numbers from 1 to 4, the alkyl group having a simple or branched chain；Phenyl base based on at least one aromatic or hetero-aromatic substrate； benzhydryl base； 1-naphthalenyl or 2-naphthalenyl base； benzothiophenyl base selected from a group of substrates: 2-benzothiophenyl, 3-benzothiophenyl, 4-benzothiophenyl or 5-benzothiophenyl, a favourable 5-benzothiophenyl base； a benzo-oxazole base selected from a group containing the bases: 3-benzo-oxazole, 4-benzo-oxazole, 5-benzo-oxazole, 6-benzo-oxazole, 7-benzo-oxazole, a favourable 5-benzo-oxazole base； an alkyl group with carbon numbers from 1 to 4,where the alkyl group has a simple or branched or cyclic chain, the beneficial alkyl group is based on at least one fluoride atom； B is the phenyl base； the phenyl base is based on one or two side bases selected from the group comprising: fluoride atoms, -SCF3, -CF3, -CHF2, -CN, -OCF3, -NO2, -OCH3, -OC2H5, an alkyl group of carbon atoms with a carbon skeleton from 1 to 4, the alkyl group having a simple or branched chain.Przedmiotem zgłoszenia jest związek o wzorze ogólnym (I) lub jego farmaceutycznie akceptowalne sole oraz ich zastosowanie do leczenia chorób o podłożu neurologicznym. We wzorze wyżej wymienionego związku x - oznacza N lub C, k - jest liczbą równą 0 lub 1, A oznacza podstawnik wybrany z grupy zawierającej: podstawnik fenylowy； podstawnik fenylowy podstawiony jednym albo dwoma albo trzema albo czterema podstawnikami bocz
