INSERM (Institut National de la Santé et de la Recherche Médicale);INSTITUT PASTEUR
发明人:
James Di Santo,Jean-Jacques Mention
申请号：
US14182773
公开号：
US09439404B2
申请日:
2014.02.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a transgenic animal model system based on the development of transgenic mice bearing components of the human immune system. Specifically, the invention relates to a Flk2 deficient Rag−/−γc−/− transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further provides methods for increasing the numbers of functionally competent human dendritic cells and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential immune adjuvants and for developing novel therapeutics.
