PROBLEM TO BE SOLVED: To provide a method for producing a human T cell and a method for cell-based immunotherapy which can be used for supplementation or regeneration of immune function, which becomes effective tools in ameliorating pathological conditions of and improving the effect of treatment of diseases.SOLUTION: The present invention provides a method which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell, the produced human T cell retaining the TCR gene rearrangement pattern of the original human T lymphocytes. The present invention also provides a pharmaceutical composition comprising the T cell produced by the method； and a method for cell-based immunotherapy using the method.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】疾患の病態改善や治療効果の向上などに有効な手段となる免疫機能の補充や再生に利用できるヒトＴ細胞の製造方法および免疫細胞治療の方法の提供。【解決手段】ヒトＴ細胞からｉＰＳ細胞を誘導する工程と、該ｉＰＳ細胞をＴ細胞に分化させる工程とを含む、元のヒトＴリンパ球が有していたＴＣＲ遺伝子の組み換え構造を保ったままのヒトＴ細胞を製造する方法、該方法によって製造されたＴ細胞を含有する医薬組成物、並びに該方法を利用する免疫細胞治療の方法。【選択図】なし
