PROBLEM TO BE SOLVED: To provide a novel compound with a serotonin 5-HT6 receptor antagonistic activity which is useful to prepare a medicine for the prophylaxis or treatment of various troubles of a central nerve system, in detail for anxiety, depression, cognitive memory disorder and senile dementia, or other Alzheimers diseases which make a cognitive defect as the cardinal symptom, psychosis, child attention-deficit disorder (ADHD or attention-deficit/hyperactivity nature trouble), and moreover other troubles which are influenced by a serotonin 5-HT6 receptor in a mammal including a human.SOLUTION: The invention relates to: novel sulphonamide derivatives having general formula (I) and to the physiologically-acceptable salts thereof the methods of preparing the sulphonamide derivatives the application thereof as medicaments for human and/or veterinary therapy and the pharmaceutical compositions containing the same.COPYRIGHT: (C)2010,JPO&INPIT【課題】ヒトを含む哺乳動物において、中枢神経系の様々な障害、詳細には、不安、鬱病、認知記憶障害及び老年痴呆、又は認知欠陥をその主症状とするその他の痴呆症、精神病、小児多動症(ADHD、注意欠陥/過活動性障害)、また、セロトニン5-HT6受容体により影響を受けるその他の障害の、予防又は治療用医薬の製造に有用な、セロトニン5-HT6受容体拮抗活性を持つ新規化合物を提示する。【解決手段】本発明は、一般構造式(I)を有する新規スルホンアミド誘導体類とその生理的許容塩、前記スルホンアミド誘導体類の製造方法、ヒト及び/又は動物治療用医薬としてのその応用、及び同化合物を含む薬剤組成物に関する。(I)【選択図】なし
