Attention deficit / hyperactivity disorder model mouse, method for verifying the effect of preventing and alleviating concentration disorder using the model mouse, and method for treating concentration disorder by inhibiting T-type calcium channels
The present invention relates to an Attention deficit and hyperactivity disorder(ADHD) mouse model and a screening method for a composition for the prevention and treatment of attention deficit disease. The mouse model constructed by inserting cobalt wire in the right side of the frontal lobe is very useful as the ADHD mouse model, and the said ADHD mouse model can be effectively used for the screening of an agent for the treatment of attention deficit disease since the mouse demonstrated brain wave with low frequency, hyperactivity, and cognitive impairment, which are characteristic symptoms of attention deficit disease, when ethosuximide, one of T-type calcium channel blockers, was administered. Therefore, the composition comprising a T-type calcium channel blocker was also confirmed to be effectively used for the prevention and treatment of attention deficit disease.本発明は、注意力欠陥・多動性モデルマウス、ならびにそれを用いた集中力障害疾病の予防及び治療用組成物のスクリーニング方法に関する。より詳細には、コバルト線を前頭葉の右側に挿入した動物モデルが注意力欠陥・多動性モデルマウスとして有用であり、前記動物モデルにＴ－タイプカルシウムチャンネル抑制剤のひとつであるエトスクシミドを投与することで、集中力障害の特徴である低い周波数の脳波、過剰行動、及び認知機能の低下が観察される結果を通じて、注意力欠陥・多動性モデルマウスを用いて集中力障害治療剤のスクリーニングに活用することができ、Ｔ－タイプカルシウムチャンネル抑制剤を含む組成物を集中力障害の予防及び治療に有用に使用できることを確認した。
