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NEUE PHARMAZEUTISCHE STATIN-ZUSAMMENSETZUNG
专利权人:
HEXAL AG
发明人:
TAEUBRICH, THERESA,ROTHER, PATRICK
申请号:
EP12806375.7
公开号:
EP2787987B1
申请日:
2012.12.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The invention relates to a pharmaceutical composition, comprising or consisting of: 10 to 30 weight percent of at least a pharmaceutically active amount of a pharmaceutical substance selected from the group comprising statins, in particular water-insoluble, oxidatively degradable statins, preferably cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, or combinations thereof, 30 to 70 weight percent of lactose hydrate, 2 to 15 weight percent of microcrystalline cellulose, 5 to 25 weight percent of a partially water-soluble starch, 0.2 to 4 weight percent of at least one alkali and/or alkaline-earth salt of stearic acid and/or stearyl fumaric acid, wherein the composition contains no antioxidatively active substances such as chain terminators, reductants, free-radical scavengers, and complexing agents. The invention further relates to a method for the production thereof, to a composition that can be obtained in the method, and to the use of the pharmaceutical composition according to the invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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